News

Furosemide

Frusemide structural formula

Structural formula

Business number 016C
Molecular formula C12H11ClN2O5S
Molecular weight 330.74
label

furosemide,

Diuretic,

furaniline,

sulfonamide,

Abdominal acidity,

4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid,

5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

Numbering system

CAS number:54-31-9

MDL number:MFCD00010549

EINECS number:200-203-6

RTECS number:CB2625000

BRN number:None

PubChem number:24277714

Physical property data

1. Character:White or off-white crystalline powder, odorless, almost tasteless.


2. Density (g/mL,25/4): Undetermined


3. Relative vapor density (g/mL,AIR=1): Undetermined


4. Melting point (ºC): 206


5. Boiling point (ºC,Normal pressure): Undetermined


6. Boiling point (ºC,5.2kPa): Undetermined


7. Refractive index: Undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (º): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa,25ºC): Undetermined


12. Saturated vapor pressure (kPa,60ºC): Undetermined


13. Heat of combustion (KJ/mol): Undetermined


14. Critical temperature (ºC): Undetermined


15. Critical pressure (KPa): Undetermined


16. Oil and water (octanol/Log value of partition coefficient for water: undetermined


17. Explosion limit (%,V/V): Undetermined


18. Lower explosion limit (%,V/V): Undetermined


19. Solubility:Soluble in acetone, methanol, dimethylformamide, slightly soluble in ethanol, insoluble in water

Toxicological data

None

Ecological data

None

Molecular structure data


1. Molar refractive index: 75.76


2. Molar volume (m3/mol ): 205.8


3. isotonic specific volume (90.2K):606.2


4. Surface Tension (dyne/cm):75.2


5. Polarizability10-24cm3):30.03


Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 7

4. Number of rotatable chemical bonds: 5

5. Number of tautomers: 4

6. Topological molecule polar surface area 131

7. Number of heavy atoms: 21

8. Surface charge: 0

9. Complexity: 481

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed and stored in a cool, dry place.

Synthesis method

From 2, 4-dichlorobenzoic acid (see 12740) through chlorosulfonation, ammoniation and acidification to obtain 2, 4-dichloro-5-Sulfamoyl benzoic acid is then condensed with furfurylamine to produce furosemide.

Purpose

This product has a strong but short-lived diuretic effect. It is a powerful diuretic and is used to treat edema caused by heart, liver, kidney and other diseases. , especially in cases where base diuretics are ineffective; it can be used to treat acute pulmonary edema, cerebral edema, acute renal failure, hypertension and other diseases; combined with rehydration, this product can promote the non-excretion of poisons.

extended-reading:https://www.newtopchem.com/archives/555
extended-reading:https://www.bdmaee.net/dabco-eg-33-triethylenediamine-in-eg-solution-pc-cat-td-33eg/
extended-reading:https://www.bdmaee.net/dabco-mp602-delayed-amine-catalyst-non-emission-amine-catalyst/
extended-reading:https://www.morpholine.org/n-acetylmorpholine/
extended-reading:https://www.cyclohexylamine.net/delayed-catalyst-for-foaming-dabco-dc2-polyurethane-catalyst-dabco-dc2/
extended-reading:https://www.bdmaee.net/wp-content/uploads/2022/08/115-8.jpg
extended-reading:https://www.bdmaee.net/n-n-dimethyl-ethanolamine/
extended-reading:https://www.newtopchem.com/archives/685
extended-reading:https://www.cyclohexylamine.net/dabco-ne600-no-emission-amine-catalyst/
extended-reading:https://www.cyclohexylamine.net/high-quality-bis2dimethylaminoethylether-22%e2%80%b2-oxybisnn-dimethylethylamine-cas-3033-62-3-bdmaee/

Tags:
Prev:
Next: